利钾尿肽与心钠素在急性脑血管疾病中的作用

Role of kaliuretic peptide and atrial natriuretic peptide in acute cerebral vascular diseases

目的 :探讨利钾尿肽 (KP)与心钠素摩尔比在急性脑血管疾病 (ACVD)中的意义。方法 :用放射免疫分析方法测定 34例ACVD患者发病不同时期血浆KP和心钠素 (ANP)含量。结果 :急性脑血管疾病患者在发病第 7天血浆KP水平升高 ,病程中ANP含量明显升高 (P <0 0 5 ) ,病程第 1天、第 3天KP与ANP摩尔比显著低于对照组 (P <0 0 5 )。结论 :KP。

Objective:To investigate the role of the molar ratio of kaliuretic peptide (KP) and atrial natriuretic peptide (ANP) in acute cerebral vascular diseases(ACVD) Methods: The levels of plasma KP and ANP in 34 patients with ACVD at the different period of the course and in 24 healthy humans were determined by radioimmumoassay Results: Compared with control group, the levels of plasma KP in patients with ACVD at the seventh day after onset and plasma ANP in patients with ACVD at each point during the course were significantly increased, and the molar ratio of KP and ANP in patients with ACVD at the first and third days after onset were markedly decreased Conclusion: KP, ANP and the changes of their molar ratio might play an important role in pathogenesis of ACVD