1Wei J,Walton EA ,Milici A, et al.m1-m5 muscarinic receptor distribution in rat CNS by RT-PCR and HPLC. J Neurochem, 1994, 63: 815-821
2Hoglund AU,Baghdoyan HA. M2.M3.and M4,but not M1,muscarinic receptor subtypes are present in rat spinal cord. J Pharmcol Exp Ther, 1997, 287: 470-477
3Bartolini A, Ghelardini C, Fantetti L, et al. Role of M receptor subtypes in central antinociception. Br J pharmacol, 1992, 105: 77-82
4Naguib M,Yaksh TL.Characterization of M receptor subtypes that mediate antinociception in the rat spinal cord. Anesth Analg, 1997, 85: 847-853
5Ellis JL,Harman D,Gonzalez J, et al. Development of analgesics derived from epibatidine:role of the M4 receptor sub- type. J Pharmacol Exp Ther, 1999, 288: 1143-1150
6Ghelardini C, Galeotti N,Bartolini A, et al. Loss of muscarinic antinoception by antisense inhibition of M1 receptors. Br J Pharmacol, 2000, 129: 1633-1640
7Xu Z, Tong C, Pan HL, et al. Intravenous morphine increases release of nitric oxide from spinal cord by an adrenergic and cholinergic mechanism. J Neurophysiol, 1997, 78: 2072-2077
8Bouaziz H, Tong CY,Yoon Y, et al. Intravenous opioids stimulate norepinephine and acetylcholine release in spinal cord dorsal horn: systematic studies in sheep and an observation in human. Anesthesiology, 1996, 84: 143-147
9Taguchi K, Kato M, Kikuta J, et al. The effects of morphine-induced increases in extracellular acetylcholine levels in the rostral ventrolateral medulla of rat. J Pharmcol Exp Ther, 1999, 1539-1544
10Fang F, Proudfit HK. Spinal cholinergic and monoamine receptor mediate the antinociceptive effect of morphine microinjected in the periaqueductal gray on the rat tail, but not the feet. Brain Res, 1996, 722: 95-108
5Basile AS, Fedorova I, Zapata A, et al. Deletion of the M5 muscarinic acetylcholine receptor attenuates morphine reinforcement and withdrawal but not morphine analgesia[J]. Proc Natl Acad Sci USA, 2002, 99(17) : 11452 -11457.
6Shippenberg TS, Koob G. Recent advances in animal models of drug addiction[ M]//Davis KL, Charney D, Coyle JT, et al, eds. Neuropsycho -pharmacology: the fifth generation of progress. Philadelphia: Lippincott Williams & Wilkins, 2002:1382 - 1395.
7Kushida K, Ishida K, Kikuta J, et al. Alpha2 - adrenoceptor modulates the release of acetylcholine from the rostral ventrolateral medulla in response to morphine[J]. Biol Pharm Bull, 2003, 26( 11 ) : 1548 -1551.
8Hikida T, Kitabatake Y, Pastan I, et al. Acetyleholine enhancement in the nucleus accumbens prevents addictive behaviors of cocaine and morphine[J]. Proc Natl Acad Sci USA, 2003, 100(10) : 6169-6173.
9Rada PV, Mark GP, Taylor KM, et al. Morphine and naloxone, i.p. or locally, affect extracellular acetylcholine in the accumbens and prefrontal cortex[ J]. Pharmacol Biochem Behav, 1996, 53 (4) : 809 -816.
10Holland LN, Shuster LC, Buccafusco J J, et al. Role of spinal and superspinal muscarinic receptor in the expression of morphine withdrawal symptoms in the rat[ J]. Neuropharmcology, 1993, 32:1387 -1395.