曲唑酮改善脱毒后睡眠质量的临床观察

TREATMENT EFFECT OF TRAZODONE ON SLEEP QUALITY OF HEROIN ADDICTS

目的·· :了解曲唑酮改善脱毒后睡眠质量的效果。方法··:将97例脱毒1个月的海洛因依赖者分成不用药与用药两组进行比较。用药组每晚 po曲唑酮100-150mg,共15d。结果·· :用药组早醒次数 (0.15±s0.16次 )明显低于不用药组 (0.23±s0.18次,P<0.05) ;改善睡眠质量的总有效率为92.6 %±s2.77 %。结论·· :曲唑酮能有效改善脱毒后的睡眠质量。

Objective: To observe the effect of trazodone on sleep quality of heroin addicts under detoxification. Methods: Ninety seven heroin addicts were randomly divided into Trazodone Treatment Group (TTG)and the control according to the order in hospital. TTG started to administer trazodone 100-150 mg(po) before sleep at night after a month detoxification in hospital, and the administration lasted for 15 days. The control group did not use any drug for sleep. Results:The times of sleep-wake in TTG decreased (0.15±s 0.16) compared with that of the control(0.23±s 0.18),P<0.05 and the total rate of improvement in sleep quality was 92.6%±s 2.77%. Conclusion: Trazodone can ameliorate the sleep quality of heroin addicts during detoxification.