肺炎支原体肺炎患儿细胞因子测定的探讨

Studies on Determining the Cellular Factors in Pediatric Mycoplasma Pneumonia Patients

目的 :探讨肺炎支原体感染引起的小儿肺炎支原体肺炎与细胞因子的相关关系。方法 :91例已确诊为肺炎支原体肺炎的患儿根据肺炎支原体IgM结果。分为重症组和轻症组 ;另选 35例正常小儿为对照组。分别采取空腹静脉血 ,采用放射免疫分析法 (RIA)测定血清TNF -α ,IL - 6的水平 ,并且对三组资料进行相关性分析。结果 :重症组和轻症组血清TNF -α ,IL - 6水平明显高于正常对照组 ,差异有显著性 (P <0 0 1 ) ,重症组血清TNF -α ,IL - 6水平明显高于轻症组 ,差异有显著性 (P <0 0 5)。重症组和轻症组TNF -α ,IL - 6的资料进行直线相关分析 ,结果两组患儿TNF -α的相关系数为r =0 49,IL - 6的相关系数为r =0 95 ;显示血清TNF -α,IL - 6水平与肺炎支原体感染的严重程度呈正相关。结论 :细胞因子TNF -α,IL - 6参与肺炎支原体感染的全过程 ,并且血清TNF -α,IL -

Objective To study the interrelation between the degree of infection and changes in cellular factors in pediatrics mycoplasma pneumonia patients. Methods 91 cases of pediatric mycoplasma pneumonia were divided into a serious group and a lighter group according to the serum IgM levels. The fast serum levels of tumor necrosis factor-a (TNF-α) and interleukin-6 (IL-6) were determined with radio-immunoassay (RIA) in those patiets as well as 35 controls. Results The levels of serum TNF-α and IL-6 in both groups of patients were significantly higher than those in the controls ( P <0 01). The levels in the serious group were also significantly higher than those in the lighter group ( P <0 05). The data in patient groups were analysed with linear correlation. The correlative coefficient of TNF-α was r =0 49 and that of IL-6 was r =0 95, Suggesting positive correlationship with the seriousness of in fection. Conclusion The cellular factors TNF-α and IL-6 might participate in the whole process of mycoplasma infection and their serum levels were positively correlated with the seriausness of the disease.