脑血栓患者治疗前后血浆C型利钠多肽浓度变化及其临床意义

Study on Plasma C-type Natriuretic Peptide Levels in Cerebral Thrombosis Patients

目的 :探讨脑血栓病程与血浆C型利钠多肽 (C -typenatriureticpeptide ,CNP)含量变化之间的关系。方法 :用放射免疫分析法测定了 30例脑血栓患者发病后 1～ 3天、7～ 1 4天、2 1～ 2 8天时的血浆CNP含量。结果 :脑血栓发生后 1～ 3天血浆CNP含量较正常对照组略低 ,但无统计学意义 (P >0 0 5) ,发病后 7～ 1 4天血浆CNP含量较正常对照组明显下降 (P <0 0 1 ) ,发病后 2 1～ 2 8天CNP含量较正常对照组明显升高 (P <0 0 1 ) ,发病后的三组间血浆CNP含量差异显著 (均P <0 0 1 )。结论 :血浆CNP参与了脑血栓发生后不同阶段的病理过程 。

Objective To investigate changes of plasma C-type natriuretic peptide (CNP) levels during the cource of cerebral thrombosis. Methods Radioimmunoassay was used for determing the plasma CNP concentration in 30 normal subjects and 30 cerebral thrombosis patients before and after treatment (with 3 days, at 2 and 4 weeks). Results The plasma CNP levels in cerebral thrombosis patients within 3 days after onset didn't change markedly from those in the conrols ( P >0 05). However from day 7 to day14, the plasma CNP levels of after treatment decreased significantly ( P <0 01). The plasma CNP on 21～28th day again increased sharply ( P <0 01). Conclusion CNP might play certain important roles in the pathogenesis of cerebral thrombosis but the dynamic changes imdicated the complexity of the mechanism involved.