更年期综合征妇女雌激素替代治疗的研究

Study on Female Hormone Replacement Therapy For Climacteric Syndrome

目的 :探讨更年期综合征妇女激素替代治疗相关指标的变化及其临床意义。方法 :采用放射免疫分析法、离子电极法及酶法测定了 50例更年期综合征患者血清E2 、FSH、LH、TC、TG、LDL、HDL、ALP水平及尿Ca/Cr比值。结果 :经激素替代治疗 ,患者改良Kuppormen评分显著下降 (P <0 0 5 ,P <0 0 1 )TC、TG及LDL亦显著下降 (P <0 0 5) ,HDL略有上升 ,但统计差异无显著性 (P >0 0 5) ;E2 水平明显升高 (P <0 0 5) ,FSH及LH则显著下降 (P <0 0 5) ,ALP治疗前后无显著差异 (P >0 0 5) ,Ca/Cr比值显著下降 (P <0 0 5)。结论 :研究证实 。

Objective To study the changes of related parameters and clinical significance with female bormone replacement therapy in climacteric syndrome. Methods Radioimmunoassay and ion electrodemethod were used to determine the levels of serum E 2, FSH, LH, TC, TG, LDL, HDL and ALP in 50 cases of climacteric syndrome before and after therapy. The ratio of urinary Ca and Cr was also determineds. Results Afer treatment, LDL levels were significantly lower ( P <0 05), the levels of HDL were slightly, but not significanty elevated ( P <0 05), the levels of E 2 was significantly elevered ( P <0 05), the levels of FSH and LH were significantly lower ( P <0 05), the levels of ALP didn't change much and the ratio of Ca and Cr was significantly lower ( P <0 05). Conclusion The study confirms that estrin treatment is therupeuticly satisfactory in treatment of climacteric syndrme.