不同剂量^(131)I治疗甲状腺机能亢进症疗效观察

The Therapeutic Effect of Different Dose^(131)I on Hyperthroidism

追踪观察1228例甲亢患者两个阶段不同剂量131I治疗后的效果,并对其治疗结果进行比较。第一阶段治疗剂量为3.7～4.4MBq/g,第二阶段治疗剂量为2.59～2.96MBq/g。结果表明,剂量大时,一次治愈率比较高,但甲减的发生率也比较高;剂量小时,一次治愈率下降,所引发的甲减发生率也下降。提示今后在治疗甲亢时,应充分考虑适应症的选择、甲状腺大小估计、个体敏感性和甲亢的自然病史等方面因素,方能取得理想的治疗效果。

1 228 hyperthyroidism patients treated with two doses of 131I 3.7~4.4 MBq/g and 2.59~3.96 MBq/g are abserved and the results are compared. The results indicate that the administered dose is larger the treating rate is higher, and hypothyroidation occurs frequently; while the dose is lower, the treating rate and hypothyroidation is also getting lower. So, there are some other factors of the indication selection, the estimation of thyroidism size, individual sensitivety and the hyperthroidism nature history and so on should be considered in the hyperthroidism therapy for improving the therapeutic effect.