^(99m)Tc-TRODAT-1SPECT DAT显像评价帕金森病严重程度的研究

The study on^(99m)Tc -TRODAT-1 SPECT imaging of dopamine transporter in assessing the degree about the severityof Parkinson Disease

摘 要：目的 探讨99m Tc－TRODAT－1SPECT多巴胺转运体（dopamine transporter，DAT）显像评价帕金森病（PD）严重程度的意义。方法 对 18例健康自愿者、23例帕金森病患者行99m TC－TRODAT－1SPECT DAT断层显像，利用感兴趣区技术测定纹状体与小脑部位DAT比值。对PD患者进行UPDR评分和Hoehn－Yahr分级。结果 PD患者99m Tc－TRODAT－1SPECT DAT断层显像，纹状体DAT特异性摄取与 UPDR评分总分、日常活动评分、运动检查评分呈显著性负相关，与精神活动、行为、心境评分和PD患者年龄无相关性。结论99m Tc－TRODAT－1SPECT DAT断层显像有助于评估PD严重程度。

Abstract: Objective To evaluate the value of 99mTc -TRODAT-1 SPECT DAT imaging for assessing the degree about the severity of Parkinson Disease. Methods Eighteen healthy subjects, twenty-three patients with Parkinson Disease were studied by 99mTc -TRODAT-1 SPECT DAT imaging. Striatum specific uptake of 99mTc -TRODAT-1 was calculated according to the ratio of Striatum and cerebellum. The degree about the severity of patients with Parkinson Disease was evaluated by Unified Parkinson Disease Rating Scale (UPDRS) and Hoehn-Yahr disability score. Results Significant negative correlation were found between scores of total UPDRS,activities of Daily Living,Motor examination and the ST/CB ratio of 99Tc -TRODAT-1 uptake. There were not correlation between the score of Mentation Behavior and Mood,ages of patiens with Parkinson Disease and the ST/CB ratio. Conclusion 99mTc -TRpDAT-1 SPECT DAT imaging can help us to assess the the degree about the severity of Parkinson Disease.