肝性骨病骨密度与血清骨钙素放免测定水平的变化

VARIATION OF BONE DENSITY AND SERUM LEVEL OF OSTEOCALCIN BY RIA IN HEPATIC OSTEOPATHY

本文对24例肝硬变患者进行了血清骨钙素放免测定和双能X线骨密度及骨矿含量测定.结果17例(70.8%)腰椎2、3、4骨质密度和骨矿物含量均降低,提示骨质疏松,而X线摄片只提示3例有骨质疏松,故骨密度测定可作为肝性骨病的有效检测手段之一.24例患者中血清骨钙素异常者5例,其中升高者3例,降低者2例.骨钙素能否作为肝性骨病的敏感生化指标,尚待进一步研究.

The level of serum osteocalcin by RIA and bone density by double energy X-ray in 24 cases of cirrhosis were detected. The results showed that the bone density of the 2nd ,3rd and 4th lumbar vertebra decreased, which indicated the existence of osteoporosis , but there were only 3 cases of osteoporosis in X-ray film. So the measurement of bone density may be a sensitive means of detection for the hepatic osteopathy. There were 5 cases of abnormal level of serum osteocalcin, including 3 cases with rising level and 2 cases with declined level. Further study was needed to investigate whether the level of osteocalcin may work as an effective index for hepatic osteopathy.