尼莫地平对动物学习记忆能力的影响

Effect of Nimodipine on Learning and Memory in Animals

本文采用自动化的大鼠多次训练主动迥避反应装置——大鼠穿梭箱和小鼠一次性被动迥避反应训练装置——小鼠跳台法观察到尼莫地平可以拮抗大、小鼠学习和记忆获得及巩固过程的障碍,其作用比硝苯吡啶和长春胺各强100倍和1000～2000倍。长春胺对40％乙醇引起的小鼠记忆再现缺失有明显改善作用,但尼莫地平和硝苯吡啶则否。分析尼莫地平易化记忆的机制,除与扩张脑血管、阻断钙离子进入脑神经原内有关外,与中枢胆碱能系统的关系也值得重视。

Nimodipine was shown to facilitate acquisition and consolidation of memory as impaired by anisodine and sodium nitrite in shuttling box test on rats and step—down test on mice. Its afficacy in the improvement of memory was 100 and 1000—2000 times more potent than that of poracetam and vincamine respectively. Vincamine, not nimodipine and piracetam, was capable of improving retrieval of memory of mice impaired by 40％alcohol. The mechanisms of antiamnestic effect of nimodipine were discussed.