肝硬变患者小肠传递时间及小肠细菌过度生长的研究

STUDY ON SMALL BOWEL TRANSIT TIME AND INTESTINAL BACTERIAL OVERGROWTH IN CIRRHOTIC PATIENTS

本文首次应用国产乳果糖—氢气呼吸试验(BHT),监测了16例肝硬变患者小肠传递时间(SBTT)及小肠细菌过度生长(BOG).肝硬变SBTT为106.8±24.6min,较正常组(80.6±28.3min)显著延迟,P<0.01.其中腹水组为118.4±19.8min,较无腹水组(88.6±20.3min)显著延迟,P<0.01.BOG阳性率为37.5%,而正常组无1例阳性.6例BOG均伴有SBTT延迟,其中5例合并腹水.6例BOG服用灭滴灵1周后全部转阴.乳果糖-BHT可同时监测SBTT及BOG,故对肝硬变尤为适用.实为临床提供一种方便、可靠的检测手段.

Small bowel transit time(SBTT) and intestinal bacterial overgrowth (IBOG) were firstly investigated in 16 cirrhotic Patients by native lactulose breath hydrogen test (BHT) ,SBTT in cirrhotic group(106. 8±24. 6min) was Prolonged compared with it in the control(80. 6±28. 3min), (P< 0. 01) ;SBTT in ascitic group(118. 4±19. 8min)was prolonged compared with it in no-ascitic group (88. 6±20. 3min) , (P<0. 01)6 cases IBOG Prolonged SBTT and 5 cases complicated ascites,were found in 16 cirrhosis,and nothing in control,after treatment with metronidazole for a week,6 cases did well.