肝肾综合征患者血浆心钠素水平的变化

PLASMA LEVELS OF ATRIAL NATRIURETIC PEPTIDE IN PATIENTS WITH HEPATORENAL SYNDROME

应用放射免疫法测定了313例正常人,19例肝硬变腹水和17例肝肾综合征(HRS)患者血浆心钠素(ANP)的含量.结果表明,HRS患者ANP水平((?)±s)为854.5±96.0ng/L,明显高于正常人451.9±47.5ng/L,P<0.01;但与无肾功能损害的肝硬变腹水患者(825.3±90.6ng/L)之间无显著差异,P>0.05.肝硬变腹水患者血浆ANP与肾素、血管紧张素Ⅱ呈显著正相关,伴HRS时却无相关关系.提示HRS并不是因缺乏ANP所致,HRS时,肾脏对ANP的反应性可能进一步降低.

The plasma of atrial natrmretic peptide(ANP) were determined by radioimmunoassay in 13 healthy volunteers and 19 Patients with cirrhotic ascites and 17 Patients with hepatorenal syndrome (MRS). The results revealed: plasma ANP was 851. 5 ± 96. 0ng/L in patients with HRS corpparcd with 325. 3 ± 90. 6ng/L(P>0. 05)in Patients with cirrhosis and normal renal function and 454. 9 ± 47. 5ng/L(P<0. 01)in healthy subjects;plasma ANP showed no correlation with plasma renin activi-ty(PRA)and angiotensin II (AT II ). on the contrary, ANP positively correlated with PRA and AT II in patients without HRS. The results indicated that HRS is not caused by deficiency of circulating ANP,and might suggest a further insensitivity to the effects of ANP.