幽门螺杆菌的系列研究

A SERIES STUDY ON HELICOBACTER PYLORI

本文对幽门螺杆菌(HP)与慢性胃炎的关系,HP的生物学特性、诊断方法、治疗学等方面进行了系列研究。在100例消化不良患者中HP的阳性率在慢性浅表性胃炎为80.8％(51/63),慢性萎缩性胃炎为75％(15/20),而正常胃粘膜中为11.7％(2/17)。电镜下,HP寄居处胃粘膜微绒毛变稀疏或消失,上皮细胞粘液颗粒减少,而当HP清除后胃粘膜超微结构恢复正常,这些均提示HP的致病性。HP对酸是敏感的,其产生的尿素酶分解胃液中的尿素产氨起到了自身抗酸保护作用,此举有助于HP在胃中高酸环境中生存,并由此可以通过测定胃液尿素氮(GUN)含量来诊断HP感染。对多种诊断HP的方法进行了对比分析,认为改良Giemsa染色法和快速尿素酶试验可满足临床应用。用庆大霉素、铋剂治疗HP阳性的慢性胃炎、消化性溃疡患者取得了肯定的疗效。

There has been much progress in the study on Helicobacter Pylori (HP)since it was discovered by Marshall and Warren in 1983. The theory that HP is one of the causes of chronic active gastritis and peptic ulcer is accepted graduately by digestive Doctors. Since 1985 our department has studied the HP on bacterology,pathology,microecology,diagnostic methods and therapeutics. Of 100 patients with NUD,the HP postive rate is 80. 8% (51/65) in chronic superfical gastritis, 75%(15/20) in chronic atrophic gastritis and 11. 7%(2/17) in nonmal gastric mucosa. HP causes some special leision of gastric mucosa,such as the shorting and disappearing of microcilli and the depleting of mucosa granules in the epithelia cells. Our test shown that HP is sensitive to acid,the production of ammonia by HP through its urease activity exerts a protective antiacid effect,It can diagnosis HP infection by measuring the urea nitrogen content of gastric juice. We treat HP postive gastritis and peptic ulcer patients with Gentamycin and De-Nol,the effect is satisfactory.