大肠癌旁粘膜核仁组成区嗜银蛋白及癌胚抗原表达的研究

Study of Argyrophilic Proteins of Nucleolar Organizer Region and Carcinoembryonic Antigen in Mucosa Adjacent Colorectal Carcinoma

应用胶质银染技术及免疫组化法对31例大肠癌旁粘膜进行核仁组成区嗜银蛋白(AgNOR)形态学定量研究及癌胚抗原(CEA)检测,结果表明:从癌周组织、癌旁组织到癌组织,AgNOR计数逐渐增高(P<0.01);CEA阳性表达亦逐渐增强(P<0.01)。因此,支持大肠癌发生过程中移行粘膜理论。对AgNOR计数高、CEA表达阳性的病例追踪观察可望发现早期大肠癌。

By means of colloid staining technique and immunohistochemical method,ar-gyrophilic proteins of nucleolar organizer region (AgNOR) and carcinoembryonic antigen (CEA)in mucosa adjacent colorectal cancer were studied. The results showed that the number of AgNOR increased gradually from mucosa farther surrounding carcinoma,adjacent carcinoma to colorectol cancer. The reaction of CEA also increased. To follow up the cases with higher number of AgNOR and positive reaction of CEA can hope to detect early colorectol carcinoma.