正常国人胃液、十二指肠液、血浆胃动素水平及其关系研究

Study on the Motilin Contents of Gastrointestinal Juice and Plasma in Normal Man

本文应用放免法测定５０名献血员空腹血浆胃动素（ＭＴＬ）和其中４３名胃液及２７名十二指肠液ＭＴＬ含量。均值分别为３８１±１３９ｎｇ／Ｌ、３６３±１２４ｎｇ／Ｌ、９８７±２２３ｎｇ／Ｌ。血浆ＭＴＬ浓度男高于女，Ｐ＜０．０１。十二指肠液ＭＴＬ浓度显著高于血浆及胃液，Ｐ＜０．０１。作相关分析显示：胃液及十二指肠液ＭＴＬ分别与血浆ＭＴＬ水平均有显著正相关关系。胃液ｐＨ值与胃液ＭＴＬ浓度呈显著负相关。研究结果首次证实了人的胃肠液中具有较高ＭＴＬ水平。并提示它可能由粘膜内Ｍｏ细胞直接向腔内释放所致。所释放量与Ｍｏ细胞分布稀密程度有关。并推测Ｍｏ细胞具有双向分泌作用。

Motilin contents were detected in plasma (50 cases), gastric juice(43 cases)and duodenal juice (27 cases) by radioimmunoassay. The mean levels were 381±139 ng/L,363±124 ng/L and 987±223 ng/L respectively. There was sex difference in plasma motilin contents, P<0. 01. Duodenal juice contents of motilin were significantly higher than that of plasma and gastric juice, P<0.01. Highly singificant correlation was found between the motilin contents of plasma and that of gastrointestinal juice. Negative correlation was found bettween the motilin content of gastric juice and pH of gastric juice. The result firstly proves that there are high content of motilin in gastrointestinal juice and supports that motilin is directly secreted into lumen from Mo cell in gastrointestinal mucosa. The volume of motilin secreted is related to the density of Mo cell in mucosa. It also suggests that the secretion of motilin is two-way.