善得定治疗食管静脉曲张出血的临床对照研究

The Efficacy of Sandostatin in the Treatment of Esophageal Variceal Hemorrhage:71 Cases of Clinical Controlled Study

作者将７１例肝硬化食管静脉曲张出血患者分为３组，分别用善得定、垂体后叶素及三腔管填塞治疗。结果，善得定的止血率为９１．２％（３１／３４），平均止血时间２５．５分；垂体后叶素止血率４１．２％（７／１７），平均止血时间３７．１分；而三腔管填塞：９０％（１８／２０），６小时。善得定组、垂体后叶素组和填塞组的平均输血量分别为５６６ｍｌ，９１８ｍｌ和５５０ｍｌ。此结果显示善得定在止血率、平均止血时间和平均输血量方面均优于垂体后叶素（Ｐ＜０．００１）。善得定组的平均止血时间显著短于填塞组（Ｐ＜０．００１），但在止血率与平均输血量方面与之无明显差异（Ｐ＜０．０５）。此外，善得定的副反应轻微，观察中仅见３例患者有恶心症状。所以，作者认为，善得定是治疗食管静脉曲张出血的最佳选择之一。

cirrhotic patients with esophageal variceal hemorrhage were divided into 3 groups and managed with sandostatin, pituitarinum posterius,or tamponade. The effective rate with sandostatin was 91.2%(31/34) in mean 25. 5 minutes,while that with pituitarinum posterius was 41.2%(7/17)in mean 37.1 minutes,and with tamponade,90%(18/20)in mean 6 hours. With sandostatin,pituitarinum posterius and tamponade therapy,the average volumes of blood transfusion were 566 ml,918 ml and 550 ml respectively.The results showed that sandostatin was superior to pituitarinum posterius in the aspects of hemostatic rate, mean hemostatic time,and mean transfusive volume(P<0.001).It also had much shorter mean hemostatic time than tamponade(P<0.001),but without significant differences to it in hemostatic rate and mean transfusive volume (P<0.05).Furthermore,the side effects of sandostatin therapy were mild with only 3 cases of nauseation in the study.Therefore,the authors concluded that sandostatin is one of the best options in the management of esophageal variceal hemorrhage.