慢性肝病患者血清十项指标的检测结果及其与肝纤维化关系

Serum Ten Parameters and Their Relation with Hepatic Fibrosis in Patients with Chronic Liver Diseases

本文报道慢迁肝、慢活肝、肝炎后肝硬化、血吸虫病早期和晚期肝纤维化（早血和晚血）共６１２例，其中１５７例经肝活检确诊，进行血清腺苷脱氨酶、甘胆酸、β２－微球蛋白、Ｎ－乙酰－β－Ｄ氨基葡萄糖苷酶、羟脯氨酸、Ⅲ型前胶原肽、谷胱甘肽－Ｓ转移酶、透明质酸、肿瘤坏死因子－α及可溶性白细胞介素Ⅱ受体的检测结果。肝组织病理学检查结果显示肝纤维化程度：迁肝＜晚血＜慢活肝＜肝炎后肝硬化，而肝脏的炎症坏死程度则以慢活肝＞肝炎后肝硬化，余均较轻。１０项血清指标阳性（＞＋２ｓ）率，与肝纤维化程度，肝脏炎症和坏死有关，这些指标中没有一个属肝纤维化特异性的标志，但可用于观察肝纤维化的变化。

Serum adenosine deaminase(ADA),cholylglycine(CG),β2-microglobulin(β2-M),N-acetyl-β-D-glucosaminidase(NAG),hydroxyproline(Hyp) ,procollagen peptide of coliagen typeⅢ(PⅢP),glutathione s-transferase (GST),hyaluronic acid(HA),tumor necrosis factor-α(TNF)and:soluble IL-2 receptor(sIL-2R) were measured in 612 patients(157 cases diagnosed by biopsy)with chronic persistent hepatitis(CAH),chronic active hepatitis(CAH),post-hepatitis liver cirrhosis (LC),the early and late hepatic fibrosis of schistosomiasis(the early,the late).Histopathogical examination shows that the degree of hepatic fibrosis is CAH>LC,the rest is light.The positive rates of ten parameters are related to hepatic fibrosis degree,inflammation and riecrosis. None of these parameters is specific in hepatic fibrosis but they should be used for monitoring the fibrotic process.