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Ag-NOR计数在判断大肠癌预后中的价值

Prognostic Value of Nucleolar Organizer Regions in Colorectal Carcinoma
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摘要 应用胶质银染技术对56例根治性手术切除的大肠癌标本进行了定量观察。结果发现,Ag-NOR计数与患者的存活时间呈负相关(r=-0.77P<0.001)。Ag-NOR<4个/核,5年累积生存率是80%,Ag-NOR4~6个/核为15%,>6/核为零。对数秩时序检验P<0.001。恶性程度低的肿瘤其颗粒分布以中央型为主,似恶性程度越高颗粒分布越弥散。大肠癌细胞核Ag-NOR计数与DNA含量有一定相关性。多因素生存分析显示Ag-NOR计数是大肠癌一个重要预后指标。 NORs were quantified in a series of 56 colorectal carcinoma of radical resection using the silver-colloid method. The results showed that there was a negative correlation between mean counts of Ag-NOR and patients survival time (r=-0.77,P<0.001). From the Kaplan-Meier survival curves,we could know that the 5-year survival rates of Ag-NOR (<4.4~6,>6) were 80%,15%, and 0,respectively (P<0.001).Ag-NOR was mainly located in the center of nucleus in low malignant tumor and scattered in the nucleus in high malignant tumor. There was a correlation between Ag-NOR counts and DNA content.The result of a multivariate regression analysis documented that Ag-NOR counts was an important prognostic parament.
出处 《胃肠病学和肝病学杂志》 CAS 1994年第4期268-271,共4页 Chinese Journal of Gastroenterology and Hepatology
关键词 核仁组成区 大肠癌 预后 Ag-NOR colorectal carcinoma prognosis
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