异博定治疗高血压病45例临床观察

Clinical Observation of the Effect of Verapemil on 45 Cases of Hypertension

按1979年兰州会议标准,使用异博定治疗45例高血压病,每天总剂量240mg,疗程定为8周。对高血压病Ⅰ、Ⅱ期患者有效率为95.6％,显效率为82.2％。治疗前后对比,血压下降均值为3.3/2.3kPa,经方差分析(P>0.001);心率改变不大(P>0.0)5;血酯、血糖、肾功能均无影响。副作用小,优于噻嗪类利尿剂和β-阻滞剂,可作为高血压病阶梯治疗的第一线药物。

Based upon the criteria established on the Lanzhou Meeting in 1979,forty five cases of hyperten- sion were treated with verapamil. The daily dose was 240 mg and the course of treatment was 8 weeks. The total effective rate was 95.6% of which 82.2% was obviously effective in patients with I, II stage hypertension. After treatment,an average fall of blood pressure of 3.3/2.3 kPa (P<0.001) ap peared. The change in heart rate was negligible (P>0.05). No influence on renal function, blood sugar and serum lipids could could be found. Side effects of the drug was little. Verapamil is more advanta- geous than thiiazide diuretics and β-adrenergic blockers and may serve as the primary drug for the 'stepladder' threatment of hypertension.