中药验方“肝胆通”的实验研究

Experimental Studies of Proved Recipe of Chinese Materia Medica "Gandantong oral liquid"

报告“肝胆通”由中药茵陈、山栀、大黄、虎杖、郁金、石斛、枳实、和黄芪等组成。另设“古方”作对比研究。选SD大鼠制作梗阻性黄疸动物模型,设5组,于不同日期分别作生化与病理检查。另选雌性豚鼠制作胆色素结石动物模型,设4组,饲养三个月,取胆囊胆汁和肝脏作生化和病理检查。结果、肝胆通与古方组对两组动物模型均有改善肝功能,保护肝细胞结构,增加胆汁流量,防止结石生成等作用。肝胆通优于古方。

A comparative study between proved recipe oral liquid Gandantong composed of 15 medicinal herbs and an ancient medical recipewas was carried out. SD rats were made models of obstructive jaun- dice,and female guinea pigs were made models of bile pigment cholelithiasis. The results showed that Gandantong could effectively decrease SGPT,SGOT, AKP. r--GT and enhance hepatic SDH activity and increase glycogen content, promote bile acid content,decrease hepatic and bile β--Glucuronidase activity and percentage of unconjugated bilirubin and lithogenic indices of the bile. It could significant- ly protect hepatic cells and decrease hepatic and serum cholesterol content and prevent gallstone forma- tion. The efficiency of Gandantong is higher than that of the ancient medical recipe. It is suggested that oral liquid Gandantong is effective in the treatment and prevention of cholelithiasis.