流行性出血热患者β_2-微球蛋白检测的临床意义

Clinical Significance of Determination of β_2-Microglobulin in Patients with Epidemic Hemorrhagic Fever

通过214例流行性出血热患者血清与尿液β_2-微球蛋白(β_2-MG)的动态检测,表明发病早期其血β_2-MG。即高达6.85±2.2mg/L,随肾功能损害的出现,血与尿β_2-MG均显著增高(分别为16.9±3.4和12.7±5.1mg/L)。尿β_2-MG≥20mg/L者临床预后欠佳。当肾功能明显改善后,尿β_2-MG显著降低(3.0±1.1mg/L)。随访23例,结果21.7％血β_2-MG持续异常,提示仍有肾功能不全。用于流行性出血热早期诊断,临床监测和判断预后等β_2-MG优于BUN和Cr。

Sequential determination of serum and urine β_2-microglobulin (β_2-MG), blood urea nitrogen (BUN) and serm creatinine(Cr)were carried out in two hundred and fourfeen cases of epidemic hem- orrhagic fiver (EHF)of different phases. The results showed that the levels of serum and urine β_2-MG were closely correlated with serum BUN and Cr in EHF patients. But the serum and urine β_2-MG was more sensitive than blood BUN and Cr in reflecting the functional state of the kidneys. It was found that the differences in the value of serum β_2-MG in mild,modeuately seveue,severe,and eritical cases were statistically significant(p<0.01),but the differences in urine β_2-MG valre among patients with EHF of variors phases were less significant. These results indicated that the elevation of serum β_2-MG value was parallel to the severity of injurt to the kidneys.