左旋咪唑等驱虫药致变态反应性脑炎21例分析

Analyses of Allergic Encephalitis Resulting from Using the Anthelmintic Levamisole

报道21例左旋咪唑等驱虫药致变态反应性脑炎,发病前均无感染和接种史。分别于服药后3～24天出现神经、精神症状;脑电图检查17例,14例异常:CT检查11例,9例为急性脱髓鞘性脑炎改变。结果:痊愈17例,好转3例,死亡1例。实践证明,早期诊断,应用激素为主的治疗预后较好。对本病的发病机理进行了探讨。

Analyses of twenty one patients with allergic encephalitis resulting from using the anthelmintic levamisole were made. There was no history of infection or vaccination in any of the patients before illness. Neuropsychic symptoms appered 3～24 day(?) after taking the above drug. EEG examination on 17 patients revealed 14 abnormal. CT scan of ients showed acute,demyelinative changes In 9. Hormone,dehydrants, neurotrophic drugs and symptomatic supportive treatments were adopted. The results were: 17 patients with complete recovery, 3 patients with improvement and 1 death. It is considered that the earlier the diagnosis and treatment with hormone,the better the prognosis is. The pathogenesis of this disease hat been discussed as well.