免疫抑制剂对日本血吸虫发育及抗体水平的影响

Effect of Immunosuppressant on the Development of Schistosoma Japonicum and the Antibody Level in the Rabbits

分别使用一定剂量的地塞米松和环磷酰胺处理日本血吸虫病免,结果血吸虫荷分别减少20.5％、36.7％,雌雄比值最低降至0.58,抗体滴度下降明显,第12周时的肉芽肿体积较第8周的缩小了一半。表明免疫抑制剂对血吸虫发育,抗体和虫卵肉芽肿形成均有显著的抑制作用,提示血吸虫病血清学检测出现假阴性可能与宿主免疫功能低下有关。

To observe the effect of immunosuppressants on S.japonicum and the host, rabbits infected with S.japonicum were given a certian dose of dexamethasome and cyclophosphamide separately. The results showed that the immunosuppressants had inhibitory effect on the development of S.japonicum, antibody level and egg granuloma formation in the hosts' liver. Both drugs reduced the worm burden by 20. 5％ and 36.7％ separately and the ratio of female to male reduced to as low as 0.58. The antibody titer decreased obviously. The volume of the egg granuloma by the 12th week was half of that by the 8th week.It is suggested that the psudonegative reaction in serological examination of schistosomiasis might be related to the Suppressed immunologic reaction of the host.