下颌骨骨折愈合的中西医结合治疗动物实验与临床应用研究

Combined Treatment of Traditional Chinese and Western Medicine in Union of Mandibular Fracture——Experimental Study and Clinical Application

为了探讨中药接骨汤在促进下颌骨骨折愈合中的作用,对12只家兔的下颌骨造成实验性骨折,并分成中药组及对照组各6只,术后2、4、6周观察标本。临床上治疗50例采用三期分治法,进行辨证论治。动物实验标本经大体形态学、X线、光镜、透射电镜表明,中药接骨汤确有促进下颌骨骨折的作用中药组优于对照组。治疗下颌骨骨折50例,随访了3～24个月,表明:(1)病人恢复了正常的咬(牙合);(2)用中西医治疗的方法,较传统的颌间固定4周,平均缩短疗程8 d;(3)临床应用中药接骨汤约1000剂,未出现毒副反应。

Traditional intermaxillary fixation has been most freguently used in the treatment of mandibular fracture. This study combined traditional Chinese medicine with Western medicine (TCM and WM)in order to observe the function of Jie Gu Tang (Chinese herbal decoction for bone fracture) in promoting healing of mandibular fractave. Twelve rabbits with experimentally fractured mandible were divided into two group, one group treated with Chinese herbal decoction and the other group for control, and observed the specimens at 2,4,6 weeks postoperatively. Clinically, 50 patients with mandibular fracture were treated with combined TCM and WM in three steps according to determination of treatment based on the differentiation of symptoms and signs. The Chinese herb group showed better results than the control group by morphology, X-Ray, Light microscopy and transmission electron microscopy. It proved that Chinese herbal decoction (containing Salvia Miltiorrzae etc.)can promote the healing of mandibular fracture. Follow-up survey of the 50 patients with mandibular fracture for 3—24 months indicated that:1. The patients treated with Chinese herbal decoction resumed normal occlusion. 2. Combined TCM and WM therapy reduced the course of treatment by 8 days from traditional treatment of intermaxillary fixation (4 weeks). 3. No toxic side-effects were found in clinical application of the Chinese herbal decoction for 1 000 times.