摘要
用免疫组化的方法(PAP法)对61例口腔鳞癌局部浸润的郎格罕氏细胞(Langerhans Cells,LCs)进行半定量观察。结果发现癌的病理分级不同,其间质LCs数量也有差异,分化高者,癌间质LCs数量多;LCs在癌间质中数量与淋巴细胞,浆细胞数有关联;LCs数还与肿瘤分期有关,但与颈淋巴结是否转移在统计学上无显著差异。其中48例口腔癌患者预后与LCs数关系的分析显示,随癌间质LCs数量的增加,生存时间延长。并对LCs在口腔癌间质中的分布,反应的意义及对口腔癌预后的评估价值进行了讨论。
Infiltrating Langerhans cells(LCs) in sixty one cases of oral squamous cell carcinoma were investigated immunohistochemically using anti-S-100 protein antibody (PAP method). Semiquantitative analysis of LCs showed the number of LCs in the stroma varied with pathological grading,being more numerous in highly differentiated carcinomas; it is also related with the number of lymphocytes and plasmocytes in the stroma and with TNM staging. But there was no significant difference statistically between with or without cervical lymph node metastasis. An analysis on the relationship between the number of LCs and the prognosis of 48 patients with oral carcinoma showed that patients survivedlonger with increased number of LCs. The distribution of LCs in the stroma of oral carcinoma, the significace of their reaction and the evaluation of their existence were discussed.
出处
《江西医学院学报》
1993年第1期43-46,共4页
Acta Academiae Medicinae Jiangxi
