小儿肺炎时血浆心钠素的改变

Changes in Plasma Atrial Natriuretic Peptide Levels in Childhood Pneumonia

用放射免疫分析方法测定了32例小儿肺炎极期和恢复期血浆心钠素(ANP)浓度。结果显示:极期心钠素水平明显增加(2456.7±1055.68 pg/ml),与正常对照组(768.92±207.34 Pg/ml)及恢复期(903.37±314.65 pg/ml)比较,差异有显著性意义(P<0.01)。其中7例肺炎合并心衰者其值更高,恢复期均接近正常水平。并初步探讨了小儿肺炎血浆心钠素升高的发病机理,提示测定血浆心钠素水平对诊断肺炎心衰有一定的临床价值,对其疗效观察有一定的指导意义。

Plasma atrial natriuretic peptide(ANP)levels were measured by radioimmunoassay in thirty two childhood pneumonia and compared with those of 48 normal controls. The plasma ANP level in the critical stage of pneumonia was 2456.7±1055.68 pg/ml (mean±SD), significantly higher than that of the control group (P<0.01). The plasma ANP level in convalescent was 903.3±314. 65pg/ml, close to normal (P>0.05), The plasma ANP level in pneumonia with congestive heart failure(CHF) was significantly higher than that in pneumonia without CHF(P<0.05), The above results suggest that plasma ANP concen—tration will be of value in diagnosing pneumonia associated with CHF and judging the efficacy of therapy in childhood pneumonia.