^(90)Sr/^(90)Yβ射线腔内照射治疗前列腺增生症的临床应用研究

The effect of^(90)Sr/^(90)Yβ-rays of benign prostatic hyperplasia

目的 观察 90 Sr/90 Yβ射线腔内治疗前列腺增生症的临床疗效。方法 将 90 Sr/90 Y治疗器活性区置于尿道前列腺段 ,实施β射线腔内照射 ,剂量为 30～ 50 Gy,治疗 37例前列腺增生病人 ,治疗后随访 3个月。结果 治疗 2 w后 ,2 6例患者临床症状明显减轻 ,7例有所好转 ,4例改善不明显。治疗前后最大尿流率、膀胱残余尿、国际前列腺症状评分及前列腺体积均发生明显的变化 (P<0 .0 1 )。结论 放射性核素 90 Sr/90 Y腔内治疗前列腺增生症效果显著 。

Objective To investigate the effect of 90 Sr/ 90 Y β rays on benign prostatic hyperplasia(BPH) Methods In order to carry out β rays intracavitary irradiation, the active area of the applicator was located into prostate gland section of urethra in 37 patients The dose was 300Gy in each patient who was observed for 3 monthes Results After two weeks 26 cases were remarkably improved, 7 cases were slightly improved and 4 cases were ineffective There was significant difference on MFR, PVR, I PSS and volumn of prostate gland before and after treatment(P<0 01) Conclusions Clinical tests indicate that the 90 Sr/ 90 Y prostatic hyperplasia applicators provide a safe, effective, non invasive and economical therapeutic method for BPH It is especially applicable for older and high risk patients