胆消灵丸辅助治疗妊娠肝内胆汁淤积症的疗效观察

Observation on Effect of Danxiaoling in Supplementary Treatment of Intr ahepatic Cholestasis in Pregnancy

目的 :评估中药胆消灵丸对妊娠肝内胆汁淤积症 (ICP)的疗效。方法 :5 8例患者随机均分为两组 ,分别用胆消灵丸 (胆消灵组 )和复方益肝灵 (对照组 )辅助治疗 ,其他常规治疗两组相同。观察两组患者治疗前后临床症状、相关指标及分娩结局。结果 :两组总有效率均为 10 0 % ,但胆消灵组显效率 (86 2 % )明显高于对照组 (5 1 7% ,P <0 0 1) ;治疗后血甘胆酸 (CGA)、丙氨酸转氨酶 (ALT)、天门冬氨酸转氨酶(AST)、碱性磷酸酶、总胆红素、总胆固醇、低密度脂蛋白胆固醇两组均有改善 ,与治疗前比较差异有显著性(P <0 0 5 ,P <0 0 1) ,但胆消灵组降CGA、ALT、AST的作用优于对照组 (P <0 0 5 ) ,并还有改善乳酸脱氢酶、甘油三酯、极低密度脂蛋白胆固醇及高密度脂蛋白胆固醇等指标的作用 ;羊水污染率、早产发生例数胆消灵组均低于对照组 ,而新生儿平均体重则高于对照组。结论 :胆消灵丸治疗ICP能有效降低血甘胆酸 。

To evaluate the curative effect of Danxiaolin g Pill (DXLP), a Chinese herbal preparation, in treating intrahepatic cholestasis in pr egnancy (ICP). Methods: Fifty eight cases of ICP were divided randomly into two groups and treated by DXLP and Composite Yiganling as control respectively w i th the other identical conventional treatment. The changes of clinical symptoms, related laboratory parameters after treatment and the condition of labor were o bserved. Results: The total effective rate in both groups was 100%, bu t the markedly effective rate in the DXLP treated group was higher than that in c ontrol group (P<0 01). Levels of blood cholyglycine acid (CGA), alanine transaminase (ALT), aspartate transaminase (AST), total bilirubin, total cholesterol and low density lipoprotein were all decreased in both groups after treatment, but DXL showed a better efficacy in decreasing CGA, ALT and AST than that of Yiganling. Moreover, the amniotic fluid meconium contaminated rate, prem ature delivery occurrence in the DXLP group were lower than those in the control group, while the weight of newborn baby was higher in the former than in the lat ter. Conclusion: DXLP could effectively lower the serum bile acid a nd improve liver function in treating ICP.