来氟米特治疗类风湿关节炎的长期随访(英文)

Leflunomide in treatment of rheumatoid arthritis——a long-term follow up

目的 :观察长期应用来氟米特治疗类风湿关节炎 (类风关 )的疗效和不良反应。方法 :2 1例类风关病人 [男性 2例 ,女性 19例 ;年龄 (45±s9)a ;病程 (5 9± 4 8)mo],首先应用来氟米特 2 0mg ,po ,qd进行为期 0 .5a的双盲、单盲试验 ,以后又继续按原剂量用药并随访 ,其中有 9例服药 6mo至 1a后改用 10mg ,po ,qd。结果 :2 1例随访 1.5a(包括双盲、单盲试验的 6mo ,下同 ) ,临床缓解 1例 ,显效 2 0例 ;19例随访 2a ,临床缓解 7例 ,显效 12例 ;17例随访 2 .5a ,临床缓解 10例 ,显效 7例 ;12例随访 3a ,临床缓解 9例 ,显效 3例。X线双手正位片 3a随访中无变化 6例。先后发生不良反应共计为 19%(4/2 1例 )。结论 :来氟米特长期治疗类风关疗效好。

AIM: To investigate the efficacy and safety of leflunomide (Lef) in long term treatment of rheumatoid arthritis (RA). METHODS: Twenty one patients [M 2,F 19; age (45± s 9)a] with RA were selected. Disease duration was (59±48) mo. All patients enrolled in double blind or single blind trials with Lef 20 mg, po, qd for 6 mo at first. Doses of leflunomide in nine patients were reduced down to 10 mg, qd and all the others continued the treatment with Lef at 20 mg, qd. RESULTS: All twenty one patients were followed up for 1.5 a. The results showed that twenty patients had remarkable improvement and one patient had clinical remission. Nineteen patients had been followed up for more than 2 a and twelve patients had remarkable improvement while seven patients had clinical remission. Twelve patients had been followed up for 3 a and three of them had remarkable improvement while nine patients had clinical remission. Total rate of adverse reactions was 19 %(4/21). CONCLUSION: This study shows that long term treatment of RA with Lef is effective and safe.