通心络对椎基底动脉系短暂性脑缺血发作病人血流动力学的影响

Influence of Tongxinluo in hemodynamics in patients with transient ischemic attack in vertebrobasilar artery system

目的 :探讨通心络对椎 基底动脉系短暂性脑缺血发作 (TIA )病人血流动力学的影响。方法 :将 6 6例TIA病人年龄以 6 0a为界分为 2组 ,均服用通心络胶囊 4粒 (每粒 0 .38g) ,tid ,疗程 4wk。结果 :治疗前后TIA病人颅内椎动脉血流速度差值为左、右侧老年组为 (4± 11)cm·s- 1和 (4± 12 )cm·s- 1,青、中年组为 (5± 10 )cm·s- 1和 (5± 11)cm·s- 1;基底动脉血流速度差值老年人组为 (6± 15 )cm·s- 1,青、中年组为 (4± 10 )cm·s- 1(P <0 .0 5或<0 .0 1) ,且老年组脉动指数较治疗前显著降低 (P<0 .0 5 )。治疗期间无明显不良反应。结论 :通心络胶囊可减轻动脉硬化程度 ,改善脑供血 ,是治疗椎

AIM: To probe the influence of Tongxinluo in hemodynamics in patients with transient ischemic attack(TIA) in vertebrobasilar artery system. METHODS: Sixty six patients with TIA in vertebrobasilar artery system were divided into two groups by 60 a old. Each patient was treated with Tongxinluo capsule 1.52 g, po , tid. The course of treatment was 4 wk. Changes of hemodynamics in patients with TIA were examined before and after treatment. RESULTS: Blood flow velocity increased significantly( P <0.05 or <0.01) in VA[senile group left and right were(4± s 11)cm·s -1 , (4±12)cm·s -1 respectively, middle aged group were (5±10)cm·s -1 , (5±11)cm·s -1 respectively], BA[senile group was (6±15)cm·s -1 , middle aged group was (4±10)cm·s -1 ] in patients with TIA after treatment with Tongxinluo. PI reduced significantly( P <0.05) in VA, BA in senile patients with TIA after treatment with Tongxinluo. There were not any adverse reactions during the treatment. CONCLUSION: Tongxinluo is an effective drug in patients with TIA and it can prevent ischemic stroke efficaciously.