摘要
胎儿生长发育不良与其成年后糖耐量减低 (IGT)和 2型糖尿病 (T2DM)的高发生率有关。胎儿出生时的大小取决于宫内生长环境而不是遗传因素。“节俭表现型假说”认为胎儿为适应不利的宫内环境 ,改变生长发育的“程序化”过程 ,而这些改变保持下来 ,最终导致IGT、T2DM。
出处
《国外医学（内分泌学分册）》
2002年第1期14-16,共3页
Foreign Medical Sciences(Section of Endocrinology)
参考文献11
-
1Hales C N,Barker D J P.Type 2 (non-insulin dependent) diabetes mellitus:the thrifty phenotype hypothesis [J].Diabetologia,1992,35:595-610.
-
2Forsen T,Eriksson J,Tuomilehto J,et al.The fetal and childhood growth of persons who develop type 2 diabetes [J].Ann Intern Med,2000,133:176-182.
-
3Rich-Edwards J W,Colditz G A,Stampfer M J,et al.Birthweight and the risk for type 2 diabetes mellitus in adult women [J].Ann Intern Med,1999,130:278-284.
-
4Dabelea D,Pettitt D J,Hanson R L,et al.Birth weight, type 2 diabetes,and insulin resistance in Pima Indian children and young adults [J].Diabetes Care,1999,22:944-950.
-
5Martin J F,Johnston C S,Han C T,et al.Nutritional origins of insulin resistance:a rat model for diabetes-prone human populations [J].J Nutr,2000,130:741-744.
-
6Lithell H O,Mckeigue P M,Berglund L,et al.Relationship of birthweight and ponderal index to noninsulin-dependent diabetes and insulin response to glucose challenge in men aged 50-60 years [J].BMJ,1996,312:406-410.
-
7Martin M A,Alvarez C,Goya L,et al.Insulin secretion in adult rats that had experienced different underfeeding patterns during their development [J].Am J Physiol,1997,272:E634-E640.
-
8Crowther N J,Cameron N,Trusler J,et al.Association between poor glucose tolerance and rapid post natal weight gain in seven-year-old children [J].Diabetologia,1998,41:1163-1167.
-
9Poulsen P,Vaag A A,Kyvic K O,et al.Low birthweight is associated with NIDDM in discordant monozygotic and dizygotic twin pairs [J].Diabetologia,1997,40:439-446.
-
10Bo S,Cavallo-Perin P,Scaglione L,et al.Low birthweight and metabolic abnormalities in twins with increased susceptibility to Type 2 diabetes mellitus [J].Diabet Med,2000,17:365-370.
同被引文献13
-
1乔会珍,于雅琴,史杰萍,刘雅文,刘青,刘娅.MT1X基因多态性与2型糖尿病的关系[J].吉林大学学报（医学版）,2006,32(1):97-99. 被引量：1
-
2刘青,郭蔚莹,迟宝荣.脂联素与胰岛素抵抗及2型糖尿病关系的研究进展[J].吉林大学学报（医学版）,2006,32(6):1142-1145. 被引量：7
-
3王芳,郝翠芳.雄激素受体基因微卫星CAG多态性与PCOS高雄激素血症关系的临床观察[J].中国计划生育学杂志,2007,15(1):39-42. 被引量：9
-
4Almeida S, Hutz MH. Estrogen receptor 1 gene polymorphisms in premenopausal women: interaction between genotype and smoking on lipid levels[J]. Braz J Med Biol Res, 2008, 41 (10): 872-876.
-
5Ricchiuti V, I.ian CG, Oestreicher EM, et al. Estradiol increases angiotensin II type 1 receptor in hearts of ovarieetomized rats [J].J Endocrinol, 2009, 200 (1): 75- 84.
-
6Dahhnan I, Vaxillaire M, Nilsson M, et al. Estrogen receptor alpha gene variants associate with type 2 diabetes and fasting plasma glucose [J].Pharmacogenet Genomics, 2008, 18 ( 11 ) :967-975.
-
7Horenburg S, Fischer-Posovszky P, Debatin KM, et al. Influence of sex hormones on adiponectin expression in human adipocytes [J]. Horm Metab Res, 2008, 40 (11): 779-786.
-
8Leak TS, Mychaleckyj JC, Smith SG, et al. Evaluation of a SNP map of 6q24-27 confirms diabetic nephropathy loci and identifies novel associations in type 2 diabetes patients with ncphropathy from an African American population [J]. Hum Genet, 2008, 124 (1): 63- 71.
-
9张亚光 王淑琴 廖雪松等.糖尿病肾病大鼠肾脏磷脂酶A2活性变化及Ⅱ型磷脂酶A2mRNA的表达.肾脏病与透析肾移植杂志,1(2):66-67.
-
10官鑫.雌激素受体a基因多态性与2型糖尿病的关系[D].长春:吉林大学,2010.
二级引证文献5
-
1石鑫,官鑫,唐媛,吕乐,乔乙春,刘雅文,李勇,程熠.类固醇受体辅激活因子1基因多态性与2型糖尿病的关联性分析[J].吉林大学学报（医学版）,2013,39(6):1237-1241. 被引量：2
-
2杨晓乐,时燕萍.雌激素受体基因α多态性与子宫肌瘤易感关系的研究[J].新疆医科大学学报,2014,37(2):248-251. 被引量：4
-
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-
4周玉彬,李超,詹瑛,乔炳龙,徐琳,马春玲,卢彩霞,赵蕾.ERα基因多态性与妊娠期糖尿病发病的关系[J].中华妇产科杂志,2016,51(10):773-776. 被引量：5
-
5周玉彬,李超,乔炳龙,齐卫红,徐琳,马春玲,盛忠峰.妊娠期糖尿病患者胎盘组织中雌激素与雌激素受体α水平变化及相关因素分析[J].中华糖尿病杂志,2017,9(11):688-692. 被引量：18
-
1杨屏日,胡旭君,赵正言.宫内环境及出生体重与代谢综合征[J].国际儿科学杂志,2015,42(1):44-47. 被引量：1
-
2刘菲,高雪莲.影响成年期糖尿病发病的围产期危险因素[J].中华围产医学杂志,2009,12(4):313-313.
-
3李云珠.婴幼儿过敏性疾病的饮食干预[J].上海医学,2005,28(8):634-636.
-
4程青,沈宗姬.IGF-1、IGFBP-3及瘦素与巨大儿的相关性[J].浙江临床医学,2009,11(12):1277-1279. 被引量：2
-
5徐潜.话说疟疾[J].中老年保健,1995(5):9-9.
-
6高文静,李立明.澳大利亚双生子登记系统概述[J].中华流行病学杂志,2010,31(6):700-702.
-
7李连喜.患甲减终身服药不可怕[J].保健与生活,2016,0(6):26-26.
-
8宋斌,陈捷.血清TSH、TPO-Ab和CG检测在ICP诊断中的意义[J].放射免疫学杂志,2012,25(2):228-229. 被引量：1
-
9李华林,闻玉梅.炭疽杆菌毒力基因及其表达调控的研究进展[J].国外医学（微生物学分册）,2003,26(2):20-23.
-
10高光武,李玲,郭苗苗.幽门螺杆菌的药物治疗[J].世界最新医学信息文摘,2015,0(95):61-62. 被引量：4
