摘要
随着对遗传病因学及分子病理生理学研究的深入和产前诊断技术的发展和应用,大部分遗传病在妊娠中期(13~15周)即可诊断,加之基因治疗的进一步成熟,宫内基因治疗成为一种很有潜力的治疗方法。本文将就目前宫内基因治疗的技术和现状及有待解决的问题作一综述。
出处
《国外医学(妇产科学分册)》
2002年第1期8-11,共4页
Foreign Medical Sciences(Obstet Gynecol Fascicle)
参考文献21
-
1Surbek DV,Holzgreve W,Jansen W,et al.Quantitative immunophenotypic characterization,cryopreservation,and enrichment of second -and third-trimester human fetal cord blood hematopoietic stem cells (progenitor cells).Am J Obstet Gynecol,1998,179(5):1228-1233
-
2Flake AW,Zanjani ED.In utero hematopoietic stem cell transplantation.JAMA,1997,278 (11):932-937
-
3Porada CD,Tran N,Eglitis M,et al.In utero gene therapy:transfer and long-term expression of the bacterial neo(r) gene in sheep after direct injection of retroviral vectors into preimmune fetuses.Hum Gene Ther,1998,9(11):1571-1585
-
4Schneider H,Adebakin S,Themis M,et al.Therapeutic plasma concentrations of human factor Ⅸ in mice after gene delivery into the amniotic cavity:a model for the prenatal treatment of haemophilia B.J Gene Med,1999,1(6):424-432
-
5Themis M,Schneider H,Kiserud T,et al.Successful expression of beta-galactosidase and factor Ⅸ transgenes in fetal and neonatal sheep after ultrasound-guided percutaneous adenovirus vector administration into the umbilical vein.Gene Ther,1999,6(7):1239-1248
-
6Iwamoto HS,Trapnell BC,McConnell CJ,et al.Pulmonary inflammation associated with repeated,prenatal exposure to an El,E3-deleted adenoviral vector in sheep.Gene Ther,1999,6(1):98-106
-
7Luther-Wyrsch A,Costello E,Thali M,et al.Stable transduction with lentiviral vectors and amplification of immature hematopoietic progenitors from cord blood of preterm human fetuses.Hum Gene Ther,2001,12(4):377-389
-
8Tarantal AF,O'Rourke JP,Case SS,et al.Rhesus Monkey model for fetal gene transfer:studies with retrovitral-based vector systems.Mol Ther,2001,3(2):128-138
-
9Mason CA,Bigras JL,O'Blenes SB,et al.Gene transfer in utero biologically engineers a patent ductus arteriosus in lambs by arresting fibronectin-dependent neointimal formation.Nat Med,1999,5 (2):176-182
-
10Gaensler KM,Tu G,Bruch S,et al.Fetal gene transfer by transuterine injection of cationic liposome-DNA complexes.Nat Biotechnol,1999,17(12):1188-1192
同被引文献25
-
1周启昌,王小艳.胎儿畸形产前诊断与干预的伦理学研究[J].中国医学伦理学,2004,17(4):55-57. 被引量:28
-
2杨励勤,朱付凡.孕妇心理的系统论思考[J].医学与哲学,2005,26(1):71-72. 被引量:8
-
3Hirose S, Farmer DL, Lee H, et al. The Exutero intrapartum treatment procedure: Look back at the EXIT[ J]. J Pediatr Surg, 2004, 39:375 - 380.
-
4Harrison M R, Keller RL, Hawgood SB, et al. A randomized trial of fetal endoscopic tracheal occlusion for severe fetal congenital diaphragnatic hemia[J]. N Engl J Med, 2003, 349:1916- 1924.
-
5Hirose S, Sydorak RM, Tsao K , et al. Spectrum of intrapartum management strategies for giant fetal cervical teratoma [ J].J Pediatr Surg, 2003,38 : 446 - 450.
-
6Danzer E, Sydorak RM, Harrison MR, et al. Mimmal access fetal surgery[ J]. Eur J Obstet Gynecol Reprod Biol, 2003,108 ( 1 ) : 3 - 13.
-
7Tranquilli A L, Giannubilo S R, Bezzeccheri V, et al. Transabdominal amnioinfusion in preterm premature rupture of membranes: a randomised controlled trial[J]. BJOG, 2005,112(6) :759 - 763.
-
8Buek J D, McVearry I, Lim E, et al. Successful external cephalic version after amnioinfusion in a patient with preterm premature rupture of membranes[J]. Am J Obstet Gynecl,2005,192(6) :2063 - 2064.
-
9Eschertzhuber S, Keller C,Mitterschifthaler G, et al. Verifying coxrect endotracheal intubation by measurement of end tidal carbon dioxide during an intrapartum treatment procedure[J]. Anesth Analg, 2005, 101(3): 658-660.
-
10Preciado DA, Rutter MJ, Greenberg JM, et al. Intrapartum management of severe fetal airway obstruction[J ]. J Otolaryngol, 2004, 33 ( 5 ) : 283 - 288.
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-
1孙艺歌.胎儿宫内治疗的现状及进展[J].今日健康,2016,15(6):352-352.
-
2李丽.妇产科病人的护理伦理问题浅析[J].中国社区医师(医学专业),2009,11(15):225-225.
-
3程凡英,李建西,赵平.纳洛酮治疗胎儿窘迫与新生儿窒息及缺氧缺血性脑病的相关性临床护理研究[J].卫生职业教育,2013,31(9):139-141. 被引量:1
-
4李晓玲,龚苏苏,谢晓炜.新生儿疼痛管理方法与培训现状[J].医学与哲学(B),2013,34(7):69-70. 被引量:6
-
5熊瑞瑞,于坤.孕妇血小板减少致连续2次胎儿脑积水1例报道[J].重庆医学,2023,52(8):1276-1277.
-
1王和.宫内基因治疗[J].实用妇产科杂志,2001,17(4):197-197.
-
2苏宁宁.心理护理在妇产科护理中的应用体会[J].大家健康(学术版),2013(2):120-120. 被引量:1
-
3何建桂,马虹.β受体阻滞剂对心力衰竭死亡率影响的研究现状[J].国外医学(内科学分册),1998,25(10):432-434. 被引量:2
-
4陈玉玲,曲长春,杨子洋,李振军,谌建军.还原型谷胱甘肽防治抗结核药物致肝损害的206例临床观察[J].中国保健,2009(19):839-839.
-
5黄霁秋,王海滨.悄无声息的丙肝杀手[J].家庭医学(下半月),2010(7):54-55.
-
6孙飞,杨泽.2型糖尿病遗传病因学研究方法进展[J].国际遗传学杂志,2009,32(3):203-207. 被引量:1
-
7宋小青,鲁舒林.长QT间期综合征的遗传病因学研究进展[J].国外医学(妇幼保健分册),1995,6(4):160-163.
-
8缪正秋.慢性乙型肝炎口服核苷(酸)类似物抗病毒治疗有待解决的问题[J].肝脏,2011,16(1):62-62. 被引量:2
-
9李军,李秀钧.线粒体基因缺陷与糖尿病研究的某些新进展[J].国外医学(内分泌学分册),2002,22(5):331-333.
-
10王刚.艾滋病与银屑病[J].国外医学(皮肤性病学分册),1995,21(1):14-16. 被引量:2