23例胃肠粘膜相关淋巴组织淋巴瘤临床病理分析

A clinical-pathologic study of 23 cases with gastrointestinal mucosa-associated lymphoid tissue lymphoma

目的 探讨胃肠粘膜相关淋巴组织 (MAL T)型淋巴瘤的临床病理特点 ,为诊断及临床治疗提供依据。方法 对 2 3例胃肠 MAL T型淋巴瘤进行临床、病理形态观察和免疫组化染色研究。结果 2 3例胃肠 MAL T型淋巴瘤 ,男性发病高于女性 ,平均年龄为 4 2 .3岁 ,临床症状无特异性。病理学上低度恶性 MAL T淋巴瘤 6例 ,高度恶性 MAL T淋巴瘤 17例。对 12例采用免疫组化染色 ,证实 11例为 B细胞性淋巴瘤 ,随访 10例 ,8例生存时间超过 5年。结论 胃肠 MAL T淋巴瘤与结内淋巴瘤不同 ,是一组具有独特临床病理特征的肿瘤 :可能与 HP感染有关 ,HP感染使胃形成获得性 MAL T并发展成 MAL T淋巴瘤 ;绝大部分为 B淋巴细胞起源 ;

Objective To study the clinical and pathological features of gastrointestinal mucosa associated lymphoid tissue lymphoma for the early diagnonosis and clinical treatment.Methods Observe the clinic and morphologic pattern and immunohistochemical stain for 23 cases with GIL MALT.Results Of 23 cases of GIL MALT,the male were more than the female and average age were 42 3.No specific symptom or sign was found.In the group,6 cases were low grade malignant B cell lymphoma of MALT type,17 cases high grade malignant B cell lymphoma of MALT type.12 cases were confirmed by immunohistochemistry and 11 cases were of B cell lymphoma.Follow up data were obtained for 10/23 cases.Five year survival rates of 80% were reported.Conclusion Unlike nodal lymphoma,GIL MALT are a group of distinctive clinicopathological tumours.(1)GIL MALT correlates to HP infection,HP infection might be the cause of the formation of MALT and might resulted in MALT lymphoma.(2)The majority of GIL MALT is the orgin from B cell.(3)The prognosis of MALT lymphoma is better than that of Gastrointestinal carcinoma.