果糖二磷酸钠镁对大鼠心肌梗死的保护作用

Protective effects of sodium magnesium fructose diphosphate on myocardial infarction in rats

目的 探讨果糖二磷酸钠镁对急性心肌梗死的保护作用及其作用机制。方法 用冠状动脉结扎法制备大鼠急性心肌梗死模型 ,观察果糖二磷酸钠镁对其心电图、心肌梗死范围以及血清和心肌组织中酶活性的影响。结果 果糖二磷酸钠镁能剂量依赖性地降低模型大鼠心电图抬高的J点及血清肌酸激酶 (CK)和乳酸脱氢酶 (LDH)活性 ;减少心肌梗死范围 ;提高心肌组织超氧化物歧化酶 (SOD)活性 ,同时降低丙二醛 (MDA)含量。结论 果糖二磷酸钠镁对急性心肌梗死具有保护作用 ,其保护作用机制与抗氧自由基作用有关。

OBJECTIVE: To investigate the protective effects and its protective mechanism of sodium magnesium fructose diphosphate(FDPM) on acute myocardial infarction. METHODS: The acute myocardial infarction model in rats were performed by the ligation of the left coronary artery. The eletrocardiogram(ECG), myocardial infarct size, change of enzymes in myocardium and serum were simultaneously monitered. RESULTS: It was found that FDPM cut down the elevation degree of J point in eletrocardiogram, decreased the lactic dehydrogenase(LDH) and creatine phosphokinase(CPK) activity in serum, reduced myocardial infarct size, and improved the activity of superoxide dismutase (SOD) and decreased the malondiadehyde (MDA) contents in myocardium, respectively. CONCLUSION: FDPM had protective effects on the acute myocardial infarction induced by the ligation, the mechanism of the protective effect may be related to its role against oxygen free radicals.