慢性镉中毒小鼠肾脏的超微结构观察

THE ULTRASTRUCTURAL OBSERVATIONS IN THE KIDNEYS OF CHRONIC CADMIUM TOXICATION

透射电镜下观察10只慢性镉中毒小鼠肾脏的超微结构变化。结果表明肾小体和近曲小管上皮细胞的超微结构均受到损伤。肾小体：毛细血管内皮细胞肿胀、增厚。血管系膜增生。血管球基膜增厚或分裂成层，基膜和内皮细胞之间或基膜的分裂之间有电子致密物沉积。近曲小管上皮细胞：胞核变形、固缩。线粒体肿胀、嵴断裂、脱落。细胞游离面微绒毛肿胀、变形、排列紊乱。细胞基底面质膜内褶减少或消失。这些超微结构的改变与某些类型肾小球肾炎的病理特征相似。

The ultrathin sections of kidneys of 10 chronic cadmium toxication mice were studied with transmission electron microscope．The results showed that the ultrastructure of renal Corpuscles and epithelial cells of proximal convoluted tubules was injured. 1) Renal corpuscle: The endothelial cells of the capillaries became swollen and thickened．The Intraglomerularmesangium proliferated．The glomerular basement membranes showed thickened or split into several layers.There appeared electron－dense materials between the glomerular basement membrane and the endothellal cells．Sometimes the electron－dense materlals also appeared between the split layers of glomerular basement membrane.2)Epithelial cells of proximal convoluted tubule:The shape of the nuclei changed and size of the nuclei reduced．The mitochondria became swollen and the cristae of mitochondria broken．The microvilli on the free surface of the cells expanded and arranged irregularly.The hasal plasma membrane infoldngs reduced or disappeared．This study suggests that the ultrastructural changes of kidneys in chronic cadmium toxication were similar to the pathologic characteristics of glomerulonephritis．