CAF方案及综合治疗方案治疗激素受体阴性乳腺癌多发性骨转移的疗效比较

Comparison of the Therapeutic Effect of CAF with that of Comprehensive Treatment Regimen in the Treatment of Breast Cancer with Multibonemetastases and Hormone Receptors Negative

目的 评价单用CAF方案及综合治疗方案 (CAF方案 +甲孕酮 +氯甲双磷酸盐 )治疗激素受体阴性乳腺癌多发性骨转移的疗效和毒副作用。方法 CAF方案 2 8例 ;综合治疗方案 3 0例。结果 综合治疗方案骨痛缓解率及骨转移灶疗效分别为 2 8/ 3 0、17/ 3 0 ,均高于单用CAF方案 15 / 2 8、9/ 2 8,其差异有显著性 ;综合治疗方案的中位生存期为 6 8月 ,稍优于CAF方案 5 7月 ,但其差异无显著性。此外 ,综合治疗方案的骨髓毒性低于CAF方案 ,其差异有显著性。结论 CAF方案 +甲孕酮

Objective To evalulate the clinical results and side-effects of comprehensive treatment regimen (ie Medoxyprogestrone Acetate,Clodronate and CAF regimen) and CAF regimen in the treatment of breast cancer with multibonemetastases and hormone receptors negative.Methods Fifty-eight patients were divided into two groups:30 patients with comprehensive treatment regimen;28 patients with CAF regimen alone.Results The alleviatory rate of skeletal pain and the curative effect of bonemetastases with comprehensive treatment regimen were 28/30、15/30 separately,and were much better than those of CAF regimen alone(15/28,9/28);the medial survival periods of the two groups were 6.8 months and 5.7 months,but with no statistical difference.In addition,myelotoxicity of comprehensive treatment regimen was much less than that of CAF regimen.Conclusions Comprehensive treatment regimen is regarded as a better regimen for breast cancer with multibonemetastases and hormone receptors negative.