美施康定直肠给药治疗晚期癌痛46例临床分析

Clinical Analysis of the Treatment of Pain in 46 Patients with Advanced Cancer by Rectal Administration MS-Contin

目的 观察美施康定直肠给药治疗癌症疼痛的止痛效果。方法 美施康定直肠给药 ,最小量 3 0mg ,q12h ;最大量 90mg ,q12h。结果 46例重度癌痛患者 ,显效 2 8例 ,有效 15例 ,无效 3例 ,总有效率 93 4%。部分病人出现副作用 ,主要有恶心、呕吐、便秘、排尿困难、嗜睡和呼吸抑制。结论 美施康定直肠给药镇痛效果肯定 ,与口服相比 。

Objective To evaluate the analgesic effect of treating cancer pain by MS-contin administered rectally.Methods 30 mg of MS-contin was given every 12 hours with initial dosage of 60 mg/day.The dosage was adjusted according to the relief of pain.Results The complete response rate was 60.8%(28 cases),the effective rate was 32.6%(15 cases),no response rate was 6.5%(3 cases),with an overall effective rate of 93.4%.The main side effects of the patients include constipation,nausea,vomiting and lethargy.Conclusions Rectal administration of MST has remarkable efficacy in cancer pain relief.Compared with oral administration,rectal administration had the same effect.No more dosage should be added by rectal administration.