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阿司匹林胶囊新剂型——益欣雪的临床观察

Clinical study of Aspirin capsule Yi Xin Xue
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摘要 目的 :研究比较阿司匹林胶囊新剂型 (益欣雪 )和片剂的临床疗效。方法 :随机选择冠心病患者分别进入益欣雪组和肠溶阿司匹林片剂组 ,服药 4周后 ,观察 ADP诱导的血小板聚集率血黏度和临床副作用。结果 :血小板聚集率、全血黏度、血浆黏度在服用益欣雪和肠溶阿司匹林片剂组均显著降低 (P<0 .0 1) ,两组患者纤维蛋白原含量服药前后均无明显降低 (P>0 .0 5 ) ,血小板聚集率与血黏度降低率两组之间无显著性差异 (P>0 .0 5 ) ,但益欣雪的胃肠道副作用明显低于片剂组 (P<0 .0 5 )。结论 :益欣雪和肠溶阿司匹林片剂均具有显著降低血小板聚集率和血黏度的作用 ,但益欣雪胃肠道不良反应轻。 Objective: To Study and compare the effect between aspirin capsule (Yi Xin Xue) and aspirin tablet. Methods: Patients with coronary heart disease were divided into the capsule group and the tablet group. Observed platelet aggregation ratio, whole blood viscosity and plasmatic viscosity induced by ADP and adverse effect after 4wk of medication. Results: Platelet aggregation ratio, whole blood viscosity and plasmatic viscosity decreased significantly in two groups(P<0.01). There was not a great decrease in fibrinogen level in two groups(P>0.05). Platelet aggregation ratio and blood viscosity reduced ratio were not markedly different between two groups(P>0.05). The ratio of gastro-intestinal adverse effect of the capsule group was lower than that of the table group(P<0.05). Conclusion: Yi Xin Xue and intestine-soluble Aspirin table can reduce both platelet aggregation ratio and blood viscosity. The ratio of adverse effect was lower in the capsule group.
作者 聂晶 郑世孟
出处 《天津药学》 2002年第1期45-47,共3页 Tianjin Pharmacy
关键词 益欣雪 肠溶阿司匹林片 冠心病 血小板聚集 血黏度 Coronary heart disease platelet aggregation blood viscosity
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