新生儿先天畸形与支原体感染

Congenital abnormalily of newborn and Mycoplasma infections

目的 了解新生儿先天畸形与支原体感染状况 ,探讨支原体感染与新生儿先天畸形的关系。 方法 采集先天畸形儿咽后壁脱落细胞 ,以套式聚合酶链反应法 (nPCR) ,检测解脲脲原体 (Uu)、人型支原体 (Mh)、生殖支原体 (Mg)和发酵支原体 (Mf) ,靶基因为 16SrRNA基因。 结果 12例先天畸形新生儿中 ,Mh阳性 10例 ,Uu阳性 5例 ,Mh、Uu双阳性 3例。未检出Mg及Mf阳性病例。 结论

Objective To investigate the morbility of Mycoplasma infections in newborn with congenital abnormality and to explore the relations between the infections and the congenital abnormality. Methods Throat swab specimens were taken from newborns with congenital abnormality, Ureaplasma urealyticum (Uu),Mycoplasma hominis (Mh), Mycoplasma genitalium(Mg),and Mycoplasma fermentans(Mf) were detected by nested polymerase chain reaction(nPCR) method. Results Of the 12 newborns with congetial abnormality, 10 cases were positive with Mh,5 cases were poistive with Uu, 3 cases were positive with Mh+Uu, and no positive case with Mg and Mf. Conclusion There is a relation among Mh and/or Uu infections and congenital abnormality of newborn.