脐血抗心磷脂抗体测定的临床意义

Clinical Significance of Anticardiolipin Antibody Detected in Umbilical Blood

目的:深入探讨抗心磷脂抗体(ACA)与妊娠并发症的关系,及对围产儿的影响。方法:选择90例产妇(妊高征30例,正常产妇60例),采用ELISA法测定脐血ACA-IgG及ACA-IgM,分阳性及阴性组进行分析。结果:ACA-IgM全部阴性,ACA-IgG阳性组胎儿宫内发育迟缓(20.69％),胎儿宫内窘迫(31.03％)、新生儿死亡(13.79％)发生率均明显高于ACA-IgG阴性组,妊高征发生的时间更早,程度更重。结论:建议将ACA阳性的孕妇列入高危妊娠范畴,并且在妊娠24周开始监测ACA-IgG,以便预测妊高征、胎儿宫内发育迟缓发生,并建议对ACA-IgG阳性婴、幼儿进行随访。

Objective: To study the clinical significance of anticardiolipin antibody (ACA) detected in umbilical blood. Methods: The ACA-IgG and ACA-IgM in umbilical blood from 90 puerpcrants (hypertension: 30, normal: 60) were detected by ELISA method. Results: The ACA-IgM was negative in all puerperants. The incidents of intrauterine growth retardation (IUGR) (20.69%), fetal distress (31.03%) and neonatal death (13.69%) in ACA-IgG( + ) group were higher than those in ACA-IgG( - ) group, and the occurrence of hypertension of pregnancy in the former was earlier and more serious than that in the latter. Conclusion: In order to prevent hypertension of pregnancy and IUGR, the gravidas with ACA-IgG ( + ) should be followed-up and their ACA-IgG should be monitored from the 24th weeks of pregnancy.