幽门螺杆菌感染患者胃液及血浆中维生素C含量的变化

Changes of Vitamin C Concentration in Gastric Juice and Plasma in Patients with H. pylori

目的:通过研究Hp感染患者胃液及血液中维生素 C(Vit C)含量的变化,探讨Hp的致病机制。方法:选取20例Hp阳性及20例Hp阴性患者,采用比色法分别测定上述两组患者血液及胃液VitC含量,用电极法测定胃液的pH值。结果:20例Hp感染组的胃液中VitC含量明显低于Hp阴性组,而血浆中的VitC含量无明显差别。低胃酸者(pH>4)的胃液及血浆VitC含量明显低于高胃酸者。结论:Hp感染可造成胃液内VitC含量下降,胃液及血液内VitC含量的变化与胃液的酸度密切相关。

Objective: To investigate the changes of vitamin C concentration in gastric juice and plasma in patients with H. pylori (Hp) and probe the pathogenesis of Hp. Methods: The concentrations of vitamin C in gastric juice and plasma were studied in 40 patients with colorimetric methods, and pH levels in gastric juice were measured with electrode. Results: Gastric juice vitamin C concentrations in 20 inpositive patients were significantly lower than those in Hp negative controls. There was no difference of plasma vitamin C levels between the Hp positive patients and the Hp negative patients. The concentrations of vitamin C in gastric juice and plasma were significantly lower in those with hypochlorhydria (pH>4) compared with those with pH<4. Conclusion: Hp infection causes a descent of gastric juice vitamin C concentrations and the levels of vitamin C in gastric juice and plasma is correlated with pH levels in gastric juice.