摘要
目的 探讨短暂性脑供血不全发作 (TIA)和脑血栓形成以及疑似脑供血不全发作患者血浆溶血磷脂酸水平的变化。方法 采用有机溶剂抽提 ,并进一步分离出溶血磷脂酸 ,以定磷方法测定。结果 TIA和脑血栓形成以及疑似脑供血不全发作患者血浆溶血磷脂酸水平均显著高于对照组 (1 0 0 μmol/L± 0 70 μmol/L) ,分别为 2 14 μmol/L± 1 0 2 μmol/L、1 5 0 μmol/L± 0 85 μmol/L、1 73μmol/L± 1 14 μmol/L血浆 (P <0 0 5 )。经抗血小板聚集药物或抗凝血药物治疗患者血浆溶血磷脂酸水平下降。结论 作为体内凝血和血栓形成过程早期释放的分子标记物 。
Objective To study the level of plasma lysophosphatidic acid (LPA) in patients with TIA, cerebral thrombosis or possible ischemic attack. Methods Phospholipid was extracted from plasma of patients with TIA, cerebral thrombosis or possible ischemic attack by organic solvent. Lysophosphatidic acid was isolated further. The quantity of LPA was determined by assaying its phosphorous component. Results LPA level of patients with TIA, cerebral thrombosis or possible ischemic attack were 2 14±1 02, 1 50±0 85, and 1 73±1 14 μmol/L blood plasma respectively, all significantly higher than that in control group (1 00±0 70 μmol/L, P <0 05). The plasma LPA level decreased after anticoagulant treatment. Conclusion As a molecular marker released by activated platelets in vivo, plasma PLA may be valuable in diagnosis of cerebral ischemic attack.
出处
《中华医学杂志》
CAS
CSCD
北大核心
2002年第4期229-231,共3页
National Medical Journal of China
基金
国家 973重点基础研究发展规划资助项目(G2 0 0 0 0 5 690 5 0 )