水稻总黄酮对小鼠学习记忆的促进作用

Improvement of Learning and Memory Functions by Rice Flavoids in Mice

目的:观察水稻总黄酮对小鼠学习记忆功能的影响。方法:采用小鼠跳台法和避暗法。结果:水稻总黄酮对M-胆碱能抑制剂樟柳碱致小鼠脑记忆获得障碍、蛋白质生物合成抑制剂环己酰亚胺致小鼠脑记忆巩固障碍、中枢抑制剂乙醇致小鼠脑记忆再现障碍、脑缺血再灌注损伤小鼠的学习记忆功能均有明显的改善作用。结论:本文提示水稻总黄酮有促智作用,这对于治疗老年性痴呆具有重要意义。

Objective: To observe the effects of rice flavoids (RF) on learning and memory functions. Methods: The step down test and the step through test in mice were used. Results: RF could significantly improve the learning and meomory ability in many dementia models, such as the impairment of acquisition of memory mice induced by M-anticholinergic agents like anisodine, the impairment of consolidation of memory in mice induced by protein biosynthesis inhibitors like actidione, the impairment of retrieval of memory in mice induced by central neuron system(CNS) deprssants like ethanol, mice after cerebral ischemia-reperfusion. Conclusion: It is suggested that RF can markedly enhance the learning and memory ability, and that is significant to prevent and cure the senile dementia.