颈动脉粥样硬化及其相关因素的探讨

Assessment of Carotid Atherosclerosis and Related Factors

目的:探讨颈动脉粥样硬化与相关危险因素的关系。方法:对200例研究对象的颈总动脉内中膜厚度(IMT)和颈动脉粥样硬化斑块进行超声检测,根据TMT分为IMT≤0.99mm组和IMT≥1.00mm组,并记录胆固醇(TC)、甘油三脂(TG)、高密度脂蛋白(HDL-c)、低密度脂蛋白(LDL-c)、载脂蛋白AI(APOAI)、载脂蛋白B_(100)(APOB_(100))、脂蛋白(α)[LP(α)]、纤维蛋白原(Fbg)、血糖(BG)、血压(BP)、体重指数(BMI)、吸烟指数及年龄等指标。结果:随着IMT增厚,颈动脉粥样硬化斑块发生率增加(P<0.01),IMT与TC、LDL-c、APOB_(100)、LP(α)、Fbg、SBP、吸烟指数及年龄呈明显正相关(P<0.05～0.01)。结论:颈动脉粥样硬化与TC、LDL-c、APOB_(100)、LP(α)、Fbg、SBP及嗜烟和年龄密切相关。定期超声监测颈动脉及检查相应危险因素对防治颈动脉粥样硬化有一定的实用参考价值。

To explore the relationship between Carotid atherosclerosis and related dangerous factors.Methods:Cervical angioultrasound was performed in 200 cases for intima-media thickness (IMT) of arteria carotis communis and carotid atherosclerosis plaque, then all cases were separated into two groups: IMT< 0.99mm group and IMT> 1.00mm group, according to the results of IMT.meanwhile, both were measured total cholesterol (TC), triglyceride (TG), high-density lipoprotein( HDL-c) , low-density lipoprotein (LDL-c) ,Apoprotein AI (ApoAI) ,Apoprotein B100(ApoB100) ,Lipoprotein (a)[LP(a)] ,Fibrinogen (Fbg) ,Blood glucose (BG),Blood pressure (BP),body mass index(BMI), smoking index and age. Results: Incidence of carotid atherosclerosis plaque increased in accordence with adding of IMT( P < 0.01) , and IMT had positive relativity with dangerous factors including TC. LDL-C,ApoB100,LP(a), Fbg, SBP, Smoking index and age ( P < 0.05 ~ 0.01) .Conclusion: Carotid atherosderosis is closely related to TC,LDL-c,ApoB100,LP(a) ,Fbg,SBP,smoking age. Periodically performed carotid ultrasound and analyzing dangerous factors have practical value in prevention and treatment of carotid atherosclerosis.