胃癌高发区农村居民血清胃蛋白酶原和胃泌素分析

Radioimmunological Analysis on Serum Pepsinogen and Gastrin of Rural Adult Residents in High Risk Area of Gastric Cancer

目的 为探讨我国胃癌高发区农村成年居民血清胃蛋白酶原Ⅰ (PepsinogenⅠ ,PGⅠ )、胃蛋白酶原Ⅱ (PGⅡ )和胃泌素 (Gastrin ,GAS)水平和分布规律。方法 以放射免疫学方法对赞皇县 15 0 4名 30岁以上居民血清PGⅠ、PGⅡ和GAS水平进行了定量分析。结果 赞皇县居民血清PGⅠ、PGⅡ、PGⅠ /PGⅡ比值和GAS值变异范围非常大 ,明显偏离正态分布 ,其中位值分别为 5 6 30 μg/L、12 5 0 μg/L、4 6和 72 0 0pg/ml。男性居民血清PGⅠ、PGⅡ、PGⅠ /PGⅡ比值 (6 4 90 μg/L、13 80 μg/L、4 85 )均明显高于女性居民 (49 95 μg/L、11 5 5 μg/L、4 4 0 ;P均 <0 0 0 0 1) ,而男女居民血清GAS水平无明显差异。不同年龄组居民血清PGⅠ、PGⅡ水平有一定差异 ,但PGⅠ /PGⅡ比值差异不明显。结论 赞皇县农村成年居民血清PGⅠ、PGⅡ、PGⅠ /PGⅡ和GAS值明显偏离正态分布。血清PG水平有显著性别差异。

Objective To explore the serum level and distribution law of PGⅠ,PGⅡ,PGⅠ/PGⅡ ratio and GAS of the rural adult residents in high risk area of gastric cancer in China.Methods Serum PGⅠ,PGⅡ,GAS levels were detected with radioimmunoassay in 1504 local residents over 30 years old.Results The serum PGⅠ,PGⅡ and GAS levels varied dramatically among the local adults and were significantly skewed from normal distribution.The median values for PGⅠ,PGⅡ,PGⅠ/PGⅡ ratio and GAS were 56.30 μg/L,12.50μg/L,4.6 and 72.00pg/ml respectively.Serum PGⅠ,PGⅡ,PGⅠ/PGⅡ ratio in male ( 64.90μg/L,13.80μg/L,4.85) were all significantly higher than those in female(49.95μg/L,11.55μg/L,4 40; P <0.0001).No sex difference was found in GAS level.There were some differences in PGⅠ,PGⅡ levels among different age groups.Conclusion The serum PGⅠ,PGⅡ,PGⅠ/PGⅡ ratio and GAS levels were significantly skewed from normal distribution.Significant age and sex differences existed in serum levels of PG and GAS