摘要
目的 探讨植物雌激素———大豆异黄酮对大鼠骨代谢生化指标的影响。方法 Wistar大鼠随机分组后 ,给予不同剂量的大豆异黄酮 ,喂养 3个月后 ,对血清中骨形成生化指标碱性磷酸酶 (AKP)、骨钙素 (BGP)和骨吸收生化指标抗酒石酸酸性磷酸酶 (STrACP)及雌二醇进行检测。结果 具有弱雌激素样作用的大豆异黄酮对实验大鼠的子宫、卵巢无刺激作用。与对照组相比 ,大豆异黄酮可影响骨代谢生化指标 ,高剂量的大豆异黄酮 (41 6mg/kg·bw)具有同时抑制骨形成和骨吸收的作用 ,使骨转化率降低 ,但对骨吸收的作用大于骨形成。结论 大豆异黄酮对骨代谢生化指标有一定的调节作用 ,能够抑制骨吸收 ,预防骨质疏松的发生。
Objective To examine the influence of phytoestrogen-soybean isoflavone on rat's biochemical markers of bone turnover.Methods Wistar rats were given different doses of isoflavone for three months after grouped at random.Serum alkaline phosphatase (ALP), tartrate-resistant acid phosphatase (TRACP),osteocalcin (OC) and 17-β-estradiol (E2) were determined by kits.Results Soybean isoflavone as a weak photoestrogen didn't have any adverse effects on uterine and ovary.Compared with the control,isoflavone could affect biochemical marker of bone turnover.Isoflavone,at the dose of 41 6mg/kg.bw,suppressed the activity of osteoblastic and osteoclastic and decrease bone turnover of rats.However,it had more effects on bone resorption than bone formation.Conclusion Isoflavone can adjust the activity of rat's bone metabolic biochemical markers;and prevent the happen of bone loss.
出处
《中国公共卫生》
CAS
CSCD
北大核心
2002年第3期293-294,共2页
Chinese Journal of Public Health
