鼻咽癌遗传特征的分离分析研究

Segregation Analysis on Pedigree Data of Nasopharyngeal Cancer

目的 研究鼻咽癌的遗传特征及鼻咽癌发病风险的关系。方法 对 1998～ 1999年广东省四会市新发鼻咽癌及配偶的家系进行调查 ,使用Logistic回归模型作复合分离分析。 结果 鼻咽癌的发病风险除受父母是否有鼻咽癌史作用外 ,还受同胞的影响。分离了家庭和环境作用 (吸烟 )后 ,鼻咽癌发病风险的遗传特征符合主基因孟德尔规律。结论 研究结果说明鼻咽癌家庭聚集可能是环境和遗传的综合作用 。

Objective To study the relationship of genetic characteristics and incidence risk of nasopharyngeal cancer(NPC).Methods The familial members of new NPC cases and their spouse in Sihui,Guangdong were interviewed.The content of interview included environmental factors,dietary intake,smoking,occupation and disease history.Results The results of complex segregation by regressive logistic model showed that the NPC risk was related with senrior brother's or sister's state besides relating with parent's state.After excluding the effect of family and smoking,the genetic characteristics of NPC susceptibility fit a mendelian transmission model.Conclusion It suggested that familial clustering of NPC was likely to be a product of genetic constitution and environmental exposures.There may be a major gene which decided the susceptibility to NPC.