中药炮制去毒机理探讨

Studies on the Mechanism of Processing Toxic Chinese Herbs

从有毒中药的炮制与其毒性改变的关系上 ,提出了炮制能改变药物毒性的因素 ,归纳为以下 7个方面 :(1)去除含毒性成分的部位 ;(2 )改变毒性成分的结构 ,使之转变成毒性较小而生理活性不减的物质 ;(3)降低毒性成分的含量 ;(4)除去非有效的水溶性毒性成分 ;(5 )破坏部分酶 ,以防有效成分发生化学变化生成毒性物质 ;(6 )破坏毒性成分结构 ,使之失去活性。 (7)辅料的解毒作用。

This paper presented 7 factors concerning the relationship between processing toxic Chinese herbs and the toxicity,ablating poisonous part;changing the structure of the toxic compositon into substance with less poison and the same efficiency;reducing the content of toxic composition;ridding the inert toxic component solvable in water;destroying some enzyme to stop the formation of poison through active constituents;destroying the venenum structure into inefficient abstance;processing by the Chinese medicine with detoxication function.