泛素-蛋白水解酶复合体通路在生殖系统中的研究进展

Ubiquitin-proteasome Pathway in Reproductive Tissues

泛素 蛋白水解酶复合体通路 (ubiquitin proteasomepathway,UPP)广泛参与机体多种代谢活动 ,如细胞周期调控、细胞凋亡、免疫和变态反应、以及多种恶性肿瘤、遗传病和神经系统疾病的发生 ,但UPP在生殖系统的研究目前仍处于起步阶段 .新近的研究资料表明UPP不仅参与精子发生、精子变态 ,以及雌雄配子结合后精子线粒体的降解等雄性生殖系统的多种生理活动 ,也与妊娠早期和正常月经周期子宫内膜的组织重建、甾体激素受体的代谢等雌性生殖系统的生理活动密切相关 .

The potential importance of ubiquitin-proteasome pathway (UPP) as a mechanism for a series of processes including cell cycle progression, apoptosis, immune and inflammatory responses, tumorigenesis and metastasis, as well as some genetic and neurodegenerative diseases has long been recognized. Nevertheless, roles of UPP in different reproductive events are only beginning to be clarified. UPP has recently been shown tu be related to a variety of male reproductive events, such as spermatogenesis, spermiogenesis, as well as many female reproductive events, including tissue remodeling of the endometrium during normal menstrual cycle and early pregnancy and the degradation of the steroid receptors. Combined with domestic situation, the emerging roles of UPP in reproductive tissues are also presented.