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新近发现的一种调节肽——生长素 被引量：5

A newly found regulation peptide ghrelin
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摘要 生长素 (ghrelin)是一种新发现的含有 2 8个氨基酸的多肽 ,1999年日本科学家Kojima最先在小鼠和人胃内分泌细胞中发现。最近又在人的下丘脑和脑干发现一种孤立的G蛋白偶联受体———促生长激素分泌受体 (GHS Rs) ,是其特异性受体 ,当生长素与其特异性受体结合后会产生一系列生物学效应 ,如刺激垂体前叶释放生长激素 ,增加食欲 ,调节能量平衡 ,促进胃酸分泌。抗生长素免疫球蛋白G可明显抑制食欲。神经肽Y(NPY)及刺鼠肽基因相关蛋白 (AGRP)的抗体或拮抗剂可阻断生长素的增食欲作用 ,生长素可使NPY基因表达增高并阻断瘦素引起的降低食欲作用。禁食、低血糖和瘦素能使生长素在胃内表达上调 ,它可能是生长激素 /胰岛素样生长因子 1轴和调节能量平衡的神经内分泌调节之间的一个新的联结纽带 。
作者 臧贵明 唐朝枢
机构地区 海军总医院 北京大学第一医院心血管病研究所
出处 《生理科学进展》 CAS CSCD 北大核心 2002年第1期48-50,共3页 Progress in Physiological Sciences
关键词 生长素 结构 功能 脑肠肽
分类号 Q57 [生物学—生物化学]
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参考文献10

  • 1Cassoni P,Papotti M,Ghe C,et al.Identification, characterization, and biological activity of specific receptors for natural ( ghrelin) and synthetic growth hormone secretagogues and analogs in human breast carcinomas and cell lines[].The Journal of Clinical Endocrinology.2001
  • 2Tolle V V,Zizzari P,Tomasetto C,et al.In vivo and in vitro effects of ghrelin/motilin-related peptide on growth hormone secretion in the rat[].Neuroendocrinology.2001
  • 3Feighner S,Tan C,Mckee K,et al.Receptor for motilin identified in the human gastrointestinal system[].Science.1999
  • 4Date Y,Murakami N,Kojima M,et al.Central effects of a novel acylated peptide , ghrelin, on growth hormone release in rats[].Biochemical and Biophysical Research Communications.2000
  • 5Natazato M,Murakami N,Date Y,et al.A role for ghrelin in the central regulation of feeding[].Nature.2001
  • 6Bednarek MA,Feighner SD,Pong SS,et al.Structurefunction studies on the new growth hormone-releasing peptide, ghrelin: minimal sequence of ghrelin necessary for activation of growth hormone secretagogue receptor 1a[].Journal of Medicinal Chemistry.2000
  • 7Hosoda H,Kojima M,Matsuo H,et al.Ghrelin and des-acyl ghrelin: two major forms of rat ghrelin peptide in gastrointestinal tissue[].Biochemical and Biophysical Research Communications.2000
  • 8Kojima M,Hosoda H,Date Y,et al.Ghrelin is a growthhormone releasing acylated peptide from stomach[].Nature.1999
  • 9Toshinai K,Mondal MS,Nakazato M.Upregulation of ghrelin expression in the stomach upon fasting, insulin-induced hypoglycemia, and leptin administration[].Biochemical and Biophysical Research Communications.2001
  • 10Tschop A,David L,Smiley L,et al.Ghrelin induces adiposity in rodents[].Nature.2000

同被引文献101

  • 1LinCHANG,JingZHAO,Gui-zhongLI,BinGENG,Chun-shuiPAN,Yong-fenQI,Chao-shuTANG.Ghrelin protects myocardium from isoproterenol-induced injury in rats[J].Acta Pharmacologica Sinica,2004,25(9):1131-1137. 被引量：21
  • 2Webster KW, Discher DJ, Bishopric NH et al. Cardioprotection in in vitro model of hypoxic preconditioning. J Mol Cell Cardiol, 1995; 27(1) :453-8.
  • 3Elz JS, Nayler WG. Quantification of calcium paradox in neonatal rat hearts. Am J Physiol, 1987; 253(6) :H1358-64.
  • 4Askawa T, Matashushita S. Thiobarbituric acid test for detecting lipid peroxide. Lipids, 1979;14(5) :401-6.
  • 5Hull-Ryde EA, Lewis WR, Veronee CD et al. Simple step gradient elution of the major high energy compounds and their catobolities in cardiac muscle using high performance liquid chromatography. J Chromatogr, 1986 ;377(25) : 165-74.
  • 6Tang CS, Liu MS. Initial externalization followed by internalization of β-adrenergic receptors in rat heart during sepsis. Am J Physiol,1996; 270(39) :R254-63.
  • 7Jones LR, Beseech HR. Isolation of canine cardiac sarcolemmal vesicles. Meth Pharmacol, 1984;5( 1 ) : 1 - 12.
  • 8Anand MB, Chauhan MS, Dhalla NS. Ca^2+ ,Mg^2+ -ATPase activities of heart sarcolem microsomes and mitochondria. J Biochem, 1977; 82(6):1731-9.
  • 9Muccioli G, Papotti M, Locatelli V et al. Binding of ^125I-labeled ghrelin to membranes from human hypothalamus and pituitary gland. J Endocrinol Invest, 2001;24(3) :RC7-9.
  • 10Gnanapavan S, Kola B, Bustin SA et al. The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans. J Clin Endocrinol Metab, 2002; 87(6) :2988.

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生理科学进展
2002年 第1期

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